Menopause News 2025: How Hormones and Lifestyle Shape Your Brain and Mental Health

Discover how menopause impacts mental health and brain function. Learn about symptoms, expert insights, and tools to enhance well-being during this life transition.

MELA AI - Menopause News 2025: How Hormones and Lifestyle Shape Your Brain and Mental Health | Menopause and mental health: The science of the menopausal brain

TL;DR: The Impact of Menopause on Brain Health and How to Manage It

Menopause causes hormonal changes that significantly affect brain health, including memory, mood, and risk of neurodegenerative diseases.

• Hormonal declines during menopause reduce gray matter and alter brain connectivity, leading to memory lapses and mood swings like anxiety or depression.
• Hot flashes and poor sleep worsen issues, though gray matter may recover post-menopause.
• Lifestyle changes like exercise, Mediterranean diets, and mental stimulation, alongside hormone therapy (HRT), can mitigate symptoms and support brain health.

Take charge of your wellness journey with balanced nutrition, active living, and expert guidance. Explore brain-healthy dining in Malta with MELA AI for personalized options.


Menopause is a natural life stage that marks the end of reproductive years, but its effects extend far beyond the ovaries. The brain undergoes structural changes during menopause, influencing memory, mood, and overall mental health. Here’s what the science says and how it impacts you.

What Does Menopause Do to the Brain?

Menopause isn’t just a matter of hormonal changes impacting reproductive health. The decline in estrogen and progesterone has profound effects on the brain because these hormones play crucial roles in cognitive function and emotional regulation.

Here is what happens at the neurological level:

  1. Loss of Gray Matter: Studies show a decrease in gray matter volume during menopause, especially in areas responsible for memory and decision-making.
  2. Brain Connectivity Changes: Certain neural pathways may be altered, impacting cognitive speed, focus, and multitasking ability.
  3. Mood Regulation: Lower levels of estrogen, which influences serotonin and dopamine (key neurotransmitters for mood), can result in increased anxiety or depression risks.

Dr. Lisa Mosconi, a neuroscientist specializing in menopause, highlights that menopause is a “neuroendocrine transition,” where brain function undergoes significant changes, similar to puberty or pregnancy.

Could Menopause Make You More Forgetful?

One of the most common complaints during menopause is “brain fog,” a term used to describe a mix of forgetfulness, lack of focus, and mental fatigue. Researchers explain this isn’t a sign of dementia, but rather a temporary shift in brain function due to declining hormone levels. Interestingly, studies at BRAVE Lab found some recovery in gray matter volume post-menopause, hinting at the brain’s ability to adapt and compensate over time.

Hot flashes and night sweats, key symptoms of menopause, may also disturb sleep, preventing the brain from consolidating memories and maintaining optimal mental clarity.

The Risk Intersection: Menopause and Alzheimer’s Disease

One of the more sobering findings in menopausal research is the link between menopause and an increased risk of Alzheimer’s disease. Scientists are discovering that this risk is higher for women with specific genetic predispositions. Additionally, studies indicate that menopause initiates metabolic changes in the brain that may elevate vulnerability to neurodegenerative diseases.

Interested in how hormones relate to brain aging? Dive into “Menopause and the Female Brain” by Dr. Lisa Mosconi for a deeper understanding.

Managing Menopause’s Mental Health Effects

Can Hormone Therapy Help?

Hormone replacement therapy (HRT) has gained increasing support in its ability to alleviate menopausal symptoms, including their neurological effects. Estrogen therapy, when started early, has shown promise in improving memory and overall cognitive function. However, it’s not suitable for everyone. Risks such as breast cancer and blood clots must be weighed carefully with a menopause-trained healthcare provider.

Lifestyle Interventions

It’s not all about medication. Lifestyle changes can also bolster brain health during menopause, including:

  1. Regular Exercise: Aerobic activities improve blood flow to the brain and reduce inflammation.
  2. Mediterranean Diet: Rich in healthy fats and fiber, this diet promotes good brain function. Ingredients like olive oil, fatty fish, and leafy greens are nutrient-dense and cognitive-boosting.
  3. Mental Stimulation: Engaging in puzzles, learning new skills, or taking up hobbies can help maintain neuroplasticity, the brain’s ability to adapt.

Why Mental Health Is Just as Important as Physical Changes

While hot flashes and weight gain are often talked about, mental health requires equal attention. Depression rates spike during menopause, and anxiety can become more pronounced. This isn’t simply situational, changes in brain chemistry directly affect emotional levels. If mood changes persist, counseling, Cognitive Behavioral Therapy (CBT), or support groups can offer relief.

What Role Does Nutrition Play?

What you eat during menopause directly interacts with brain chemistry. Incorporating nutrient-rich foods like berries, walnuts, and fermented foods can regulate neurotransmitters, ensuring emotional stability. Some evidence even links gut health to brain health, making probiotics a worthwhile addition to your diet.

Interested in exploring nutritional options for longevity and well-being? Use MELA AI to discover restaurants in Malta offering brain-healthy meals and customizable dining experiences.

The Future of Menopause Research and Mental Health

Emerging tools such as wearable devices and hormone-monitoring apps are beginning to offer personalized health tracking for menopausal women. These technologies aim to bridge the gap between symptoms and solutions, enabling evidence-based interventions. For example, continuous glucose monitors are helping women understand how hormonal changes affect diet and mental clarity.


Menopause impacts every aspect of life, from how you think to how you feel. It’s a multi-dimensional change deserving of proactive management. Eating mindfully, moving consistently, and seeking expert guidance can help you navigate this transition with resilience and grace. Explore brain-boosting restaurant options and connect with health experts on MELA AI today. Discover Malta’s top-rated eateries crafted for your optimal health!


Frequently Asked Questions About Menopause and Its Impact on Mental Health

How does menopause affect brain health and memory?

Menopause significantly impacts brain health as hormonal changes, particularly the decline of estrogen and progesterone, directly affect cognitive function and memory. Research indicates that menopause leads to a temporary loss of gray matter, particularly in areas linked to memory and decision-making. This hormonal shift can result in brain fog, which manifests as forgetfulness, lack of focus, or difficulty multitasking. However, it’s important to note that these changes are not equivalent to dementia, they are temporary and largely linked to neurochemical adjustments. Over time, studies suggest that gray matter volume may partially recover, highlighting the brain’s ability to adapt post-menopause. Additionally, sleep disturbances caused by symptoms such as hot flashes and night sweats can impair the brain’s natural memory-consolidation processes, further contributing to cognitive issues. Supporting brain health through sleep hygiene, exercise, and a nutrient-rich diet can help minimize cognitive challenges during this transition.

Can menopause increase the risk of mental health disorders like depression or anxiety?

Yes, menopause can increase the risk of mental health issues, including depression and anxiety. Hormonal fluctuations during this life stage, particularly declining estrogen levels, influence key neurotransmitters like serotonin and dopamine, which play crucial roles in emotional regulation. This hormonal imbalance can heighten the risk of mood swings, irritability, and even clinical depression or anxiety in some women. Risk factors such as a prior history of mental health conditions, additional stressors, and genetic predisposition may exacerbate vulnerability. If mood changes become persistent or unmanageable, seeking professional support through counseling or Cognitive Behavioral Therapy (CBT) can provide effective relief. For some women, hormone replacement therapy (HRT) may also alleviate mood-related symptoms. It’s vital to discuss individual risks and benefits with a healthcare provider trained in menopause care.

How can women improve brain health during menopause through nutrition?

Nutrition plays a pivotal role in supporting mental health during menopause. Incorporating foods rich in antioxidants, omega-3 fatty acids, and phytoestrogens can positively impact hormone and brain health. Some tips include:

  • Follow a Mediterranean diet: This diet emphasizes olive oil, fatty fish, leafy greens, and nuts, which promote cognitive function and reduce inflammation.
  • Include foods rich in phytoestrogens: Soy products like tofu and tempeh contain natural plant-based estrogens that may balance hormone levels.
  • Focus on gut health: Foods rich in probiotics, such as yogurt or kimchi, can regulate gut-brain connections and improve emotional stability.
    For dining in Malta, use MELA AI – Malta Restaurants Directory to find restaurants offering meals that align with brain health recommendations. This can simplify the process of eating out while prioritizing your well-being.

Should I consider hormone replacement therapy (HRT) for mental health benefits during menopause?

Hormone replacement therapy (HRT) can be a beneficial option for alleviating mental health symptoms during menopause, such as mood swings, irritability, and brain fog. Estrogen therapy, in particular, is associated with improvements in memory and cognitive function when initiated early in the menopausal transition. However, HRT is not suitable for everyone, as it may carry risks such as an increased likelihood of breast cancer or blood clots. Women need individualized consultations with menopause-trained healthcare providers to weigh the potential benefits against risks. While HRT is effective, it works best when complemented by holistic lifestyle adjustments, such as regular exercise, stress reduction, and a nutrient-rich diet focused on brain health.

What lifestyle changes can improve mental health during menopause?

Several lifestyle changes can support mental well-being during menopause:

  1. Regular Exercise: Aerobic activities like walking or running improve blood flow to the brain, reducing stress and promoting neuroplasticity.
  2. Mindfulness Practices: Meditation and deep-breathing exercises can regulate emotions and reduce anxiety levels.
  3. Consistent Sleep Hygiene: Aim to improve sleep patterns by creating a relaxing bedtime routine and managing hot flashes with cooling bed setups.
  4. Mental Stimulation: Activities like reading, puzzles, or learning new hobbies can help sustain cognitive health.
  5. Social Connections: Support groups and time with friends can help reduce feelings of isolation.
    For dining options aligned with a wellness-focused lifestyle, check out MELA AI to explore brain-healthy eateries in Malta offering fresh, balanced meals.

Can menopause affect long-term brain health, such as increasing dementia risk?

Yes, menopause can potentially increase the risk of neurodegenerative diseases like Alzheimer’s. This greater risk is attributed to a drop in estrogen, a hormone that supports cognitive function and brain metabolism. Researchers have found that menopause correlates with changes in brain structure, decreased energy production, and increased vulnerability to aging-related conditions. Women with genetic predispositions (such as carrying the APOE-e4 gene) might be at higher risk. However, proactive management strategies like maintaining cardiovascular health, staying physically active, and eating a nutrient-dense diet can mitigate these risks. Early consultation with a specialist is also advisable if there’s a family history of dementia.

How is “brain fog” during menopause different from other cognitive issues?

“Brain fog” is a temporary set of cognitive difficulties often described during menopause, including forgetfulness, reduced focus, and mental fatigue. Unlike neurodegenerative conditions such as dementia, brain fog does not signal permanent damage to the brain. Instead, it results from hormonal shifts and sleep disturbances affecting mental clarity. Once hormones stabilize post-menopause, many women report a sense of improved focus and memory, as research suggests brain plasticity begins to compensate for hormone loss. Lifestyle interventions, like stress management, proper sleep, and a diet rich in brain-supporting nutrients, can ease the effects of brain fog during this transitional phase.

How do hot flashes and sleep disruptions impact memory?

Hot flashes and night sweats, common symptoms of menopause, often disrupt sleep, leading to poor memory consolidation. The brain relies on uninterrupted sleep to integrate experiences and retain memories. Frequent awakenings, caused by these symptoms, hinder these processes and can result in “foggy” thinking the next day. Cooling bedroom environments and relaxation techniques before bed can help mitigate these symptoms. For a unique dining experience that includes sleep-supportive meals, explore MELA AI to find restaurants serving omega-3 and magnesium-rich options to promote better rest and brain recovery.

Can dietary choices in Malta support mental health during menopause?

Absolutely. Malta offers nutritious Mediterranean-inspired cuisine that aligns with boosting mental health during menopause. Dishes rich in olive oil, fish, legumes, and vegetables contribute to brain health while combating inflammation and balancing hormones. Fresh seafood helps increase omega-3 levels, promoting emotional well-being and cognitive health. For those looking for dining options committed to health promotion, the MELA AI platform lists restaurants in Malta recognized for offering meals designed with brain and hormone health in mind.

How can wearable health devices or apps help manage menopause symptoms?

Wearable devices and health apps provide valuable insights into menopause by tracking sleep patterns, hot flashes, and activity levels. These tools empower women to share summarized data with healthcare providers, leading to more personalized treatments. Hormone-monitoring apps are also emerging to track phase-specific symptoms and offer evidence-based recommendations for relief. Combining these technological solutions with platforms like MELA AI enhances quality of life, connecting health-conscious women with brain-healthy dining options and providing holistic solutions for managing menopause effectively.

About the Author

Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur. Throughout her startup experience she has applied for multiple startup grants at the EU level, in the Netherlands and Malta, and her startups received quite a few of those. She’s been living, studying and working in many countries around the globe and her extensive multicultural experience has influenced her immensely.

Violetta Bonenkamp’s expertise in CAD sector, IP protection and blockchain

Violetta Bonenkamp is recognized as a multidisciplinary expert with significant achievements in the CAD sector, intellectual property (IP) protection, and blockchain technology.

CAD Sector:

  • Violetta is the CEO and co-founder of CADChain, a deep tech startup focused on developing IP management software specifically for CAD (Computer-Aided Design) data. CADChain addresses the lack of industry standards for CAD data protection and sharing, using innovative technology to secure and manage design data.
  • She has led the company since its inception in 2018, overseeing R&D, PR, and business development, and driving the creation of products for platforms such as Autodesk Inventor, Blender, and SolidWorks.
  • Her leadership has been instrumental in scaling CADChain from a small team to a significant player in the deeptech space, with a diverse, international team.

IP Protection:

  • Violetta has built deep expertise in intellectual property, combining academic training with practical startup experience. She has taken specialized courses in IP from institutions like WIPO and the EU IPO.
  • She is known for sharing actionable strategies for startup IP protection, leveraging both legal and technological approaches, and has published guides and content on this topic for the entrepreneurial community.
  • Her work at CADChain directly addresses the need for robust IP protection in the engineering and design industries, integrating cybersecurity and compliance measures to safeguard digital assets.

Blockchain:

  • Violetta’s entry into the blockchain sector began with the founding of CADChain, which uses blockchain as a core technology for securing and managing CAD data.
  • She holds several certifications in blockchain and has participated in major hackathons and policy forums, such as the OECD Global Blockchain Policy Forum.
  • Her expertise extends to applying blockchain for IP management, ensuring data integrity, traceability, and secure sharing in the CAD industry.

Violetta is a true multiple specialist who has built expertise in Linguistics, Education, Business Management, Blockchain, Entrepreneurship, Intellectual Property, Game Design, AI, SEO, Digital Marketing, cyber security and zero code automations. Her extensive educational journey includes a Master of Arts in Linguistics and Education, an Advanced Master in Linguistics from Belgium (2006-2007), an MBA from Blekinge Institute of Technology in Sweden (2006-2008), and an Erasmus Mundus joint program European Master of Higher Education from universities in Norway, Finland, and Portugal (2009).

She is the founder of Fe/male Switch, a startup game that encourages women to enter STEM fields, and also leads CADChain, and multiple other projects like the Directory of 1,000 Startup Cities with a proprietary MeanCEO Index that ranks cities for female entrepreneurs. Violetta created the “gamepreneurship” methodology, which forms the scientific basis of her startup game. She also builds a lot of SEO tools for startups. Her achievements include being named one of the top 100 women in Europe by EU Startups in 2022 and being nominated for Impact Person of the year at the Dutch Blockchain Week. She is an author with Sifted and a speaker at different Universities. Recently she published a book on Startup Idea Validation the right way: from zero to first customers and beyond, launched a Directory of 1,500+ websites for startups to list themselves in order to gain traction and build backlinks and is building MELA AI to help local restaurants in Malta get more visibility online.

For the past several years Violetta has been living between the Netherlands and Malta, while also regularly traveling to different destinations around the globe, usually due to her entrepreneurial activities. This has led her to start writing about different locations and amenities from the POV of an entrepreneur. Here’s her recent article about the best hotels in Italy to work from.

MELA AI - Menopause News 2025: How Hormones and Lifestyle Shape Your Brain and Mental Health | Menopause and mental health: The science of the menopausal brain

Violetta Bonenkamp

Violetta Bonenkamp, also known as MeanCEO, is an experienced startup founder with an impressive educational background including an MBA and four other higher education degrees. She has over 20 years of work experience across multiple countries, including 5 years as a solopreneur and serial entrepreneur. Throughout her startup experience she has applied for multiple startup grants at the EU level, in the Netherlands and Malta, and her startups received quite a few of those. She’s been living, studying and working in many countries around the globe and her extensive multicultural experience has influenced her immensely.